NASDAQ
$40.15
$40.15

Overview

Price performance
Low
$39.33
High
$41.52
Market closed. Last updated: Nov 4, 2026, 9:00 PM UTC
$
40.15
-0.27 (-0.67%)
Average, 50 days
$48.22
$66.43
Open
$41.38
Previous close
$40.42
52-week high
$86.74
Jul 8, 2026 (5 months ago)
52-week low
$39.33
Nov 4, 2026 (2 days ago)
2.08%

Valuation & Estimates

Earnings

Financials

Insider Trading

Peer Analysis

Insights & Activity

Market Cap
6.67B
Volume
3 890 157
Total Return (3M)
-27.09%
Total Return (1Y)
-44.91%
7.66
Sector
Healthcare
Links
Tags
Healthcare
Biotechnology
NASDAQ
US
Website
ionis.com
Socials
About
Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy associated with hereditary transthyretin-mediated amyloidosis in adult patients; and WAYLIVRA, which addresses familial chylomicronemia syndrome and familial partial lipodystrophy. Ionis also maintains a robust pipeline, with several drug candidates currently in Phase 3 clinical trials. These include Eplontersen, a monthly self-administered subcutaneous injection designed for all forms of TTR amyloidosis; Olezarsen, intended for individuals with severe hypertriglyceridemia (SHTG); Donidalorsen, for patients suffering from hereditary angioedema; ION363, aimed at amyotrophic lateral sclerosis (ALS); Pelacarsen, developed for those with established cardiovascular disease and elevated lipoprotein(a); and Tofersen, which works by inhibiting the production of superoxide dismutase 1. Beyond these late-stage assets, the company is actively researching treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer. The firm engages in significant collaborations, notably a strategic partnership with Biogen Inc. Additionally, it holds licensing and collaboration agreements with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc.